LYMPHOID NEOPLASIA TEL-AML1 regulation of survivin and apoptosis via miRNA-494 and miRNA-320a
نویسندگان
چکیده
1Laboratory for Molecular Epidemiology, University of California, San Francisco, San Francisco, CA; 2St Anna’s Kinderspital, Vienna, Austria; 3Division of Biostatistics, Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA; 4Instituto Nacional de Câncer, Divisão de Medicina Experimental, Rio de Janeiro, Brazil; and 5Children’s Cancer Research Institute, Vienna, Austria
منابع مشابه
TEL-AML1 regulation of survivin and apoptosis via miRNA-494 and miRNA-320a.
There is increasing evidence that miRNA and transcription factors interact in an instructive fashion in normal and malignant hematopoiesis. We explored the impact of TEL-AML1 (ETV6-RUNX1), the most common fusion protein in childhood leukemia, on miRNA expression and the leukemic phenotype. Using RNA interference, miRNA expression arrays, and quantitative polymerase chain reaction, we identified...
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The TEL/AML1 fusion gene results from the most frequent t(12;21)(p13;q22) translocation in childhood acute lymphoblastic leukemia (ALL). Its contribution to transformation is largely unknown, in particular with respect to survival and apoptosis. We therefore silenced TEL/AML1 expression in leukemic REH cells by RNA inhibition, which eventually led to programmed cell death. Microarray and 2D gel...
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